PI(s): Momany

Primary Team Members:

IRB: 202003669 (Dagle, approved)

Funding: K99/R00 (Momany) & 2023 CMN (Rios & Momany)

Status: Sample collection

Study Design: Prospective, longitudinal; Preterm infants (GA<32 weeks) hospitalized in UIHC NICU & enrolled in PROMPT. Infant physiologic and biologic variability assessed from discarded arterial line blood samples.

Description: This project is to examine change in cortisol and 17-OHP (a related metabolite) in relate to chronic stress in the NICU. We will examine correlations between the neonatal physiologic measures (e.g. heart rate, blood pressure, respiration rate) and cortisol and 17-OHP across NICU hospitalization. We will use discarded blood samples from neonates with arterial lines in the NICU to measure cortisol and 17-OHP via TMS. We will examine relations of neonatal physiologic measures with cortisol and 17-OHP levels. This is expected to result in an enhanced understanding of the mechanisms by which neonatal physiologic changes reflect a neonatal stress response.